Cancer du sein : comment limiter les effets des traitements sur le cerveau

Par Juliette Pouyat - Journaliste scientifique Publié le 13/10/2020 Mis à jour le 15/10/2020 Edition Abonné
Article

La majorité des femmes traitées pour un cancer du sein se plaignent de troubles – plus ou moins transitoires – de la mémoire, de l’attention ou sentent que leur cerveau fonctionne moins bien ou moins vite. Est-il possible d’agir sur cet effet secondaire du traitement du cancer ? Voici ce que disent les études.

Les patients traités pour un cancer rapportent souvent des symptômes cognitifs appelés « troubles cognitifs liés au cancer » (Cancer-related cognitive impairment ou CRCI en anglais) tels que des problèmes de mémoire à court terme, de mémoire de travail, d’attention, de fonction exécutives...

Références
  1. Janelsins, M. C., Kesler, S. R., Ahles, T. A., & Morrow, G. R. (2014). Prevalence, mechanisms, and management of cancer-related cognitive impairment. International review of psychiatry (Abingdon, England), 26(1), 102–113. 
  2. Yang Y, Hendrix CC. Cancer-Related Cognitive Impairment in Breast Cancer Patients: Influences of Psychological Variables. Asia Pac J Oncol Nurs. 2018;5(3):296-306. doi:10.4103/apjon.apjon_16_18.
  3. Dhillon HM, Tannock IF, Pond GR, Renton C, Rourke SB, Vardy JL. Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy. J Cancer Surviv. 2018;12(2):178-185. 
  4. Collins, B., MacKenzie, J., Tasca, G., Scherling, C., & Smith, A. (2014). Persistent Cognitive Changes in Breast Cancer Patients 1 Year Following Completion of Chemotherapy. Journal of the International Neuropsychological Society, 20(4), 370-379. 
  5. Hodgson KD, Hutchinson AD, Wilson CJ, Nettelbeck T. A metaanalysis of the effects of chemotherapy on cognition in patients with cancer. Cancer Treat Rev 2013; 39(3): 297–304.
  6. Ganz PA, Kwan L, Castellon SA, et al. Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance. J Natl Cancer Inst. 2013;105(11):791-801. doi:10.1093/jnci/djt073.
  7. Amidi A, Christensen S, Mehlsen M, Jensen AB, Pedersen AD, Zachariae R. Long-term subjective cognitive functioning following adjuvant systemic treatment: 7-9 years follow-up of a nationwide cohort of women treated for primary breast cancer. Br J Cancer. 2015;113(5):794-801. 
  8. Winocur G, Henkelman M, Wojtowicz JM, Zhang H, Binns MA, Tannock IF. The effects of chemotherapy on cognitive function in a mouse model: a prospective study. Clin Cancer Res. 2012;18(11):3112-3121.
  9. Fardell JE, Vardy J, Monds LA, Johnston IN. The long-term impact of oxaliplatin chemotherapy on rodent cognition and peripheral neuropathy.Behav Brain Res 2015; 291: 80–88. 
  10. Dubois M, Lapinte N, Villier V, et al. Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: role of glucose as adjuvant. Neuropharmacology. 2014;79:234-248.
  11. Christie LA, Acharya MM, Parihar VK et al. Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy. Clin Cancer Res 2012; 18(7): 1954–1965.
  12. Lomeli N, Di K, Czerniawski J et al. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med 2017; 102: 274–286.
  13. Lange, M., Heutte, N., Rigal, O., Noal, S., Kurtz, J. E., Lévy, C., Allouache, D., Rieux, C., Lefel, J., Clarisse, B., Veyret, C., Barthélémy, P., Longato, N., Castel, H., Eustache, F., Giffard, B., & Joly, F. (2016). Decline in Cognitive Function in Older Adults With Early-Stage Breast Cancer After Adjuvant Treatment. The oncologist, 21(11), 1337–1348. 
  14. Lange M, Joly F, Vardy J, et al. Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors. Ann Oncol. 2019;30(12):1925-1940.
  15. Lange M, Licaj I, Clarisse B et al. Cognitive complaints in cancer survivors and expectations for support: results from a web-based survey. Cancer Med 2019; 8(5): 2654–2663.
  16. Karschnia P, Parsons MW, Dietrich J. Pharmacologic management of cognitive impairment induced by cancer therapy. Lancet Oncol 2019; 20(2): e92–e102.
  17. Lyons L, ElBeltagy M, Bennett G, Wigmore P. Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery. PLoS One 2012; 7(1): e30010.
  18. Janelsins, M. C., Peppone, L. J., Heckler, C. E., Kesler, S. R., Sprod, L. K., Atkins, J., Melnik, M., Kamen, C., Giguere, J., Messino, M. J., Mohile, S. G., & Mustian, K. M. (2016). YOCAS©® Yoga Reduces Self-reported Memory Difficulty in Cancer Survivors in a Nationwide Randomized Clinical Trial: Investigating Relationships Between Memory and Sleep. Integrative cancer therapies, 15(3), 263–271. 
  19. Winocur, G., Wojtowicz, J.M., Huang, J. et al. Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats. Psychopharmacology 231, 2311–2320 (2014).
  20. Oh B, Butow PN, Mullan BA, et al. Effect of medical Qigong on cognitive function, quality of life, and a biomarker of inflammation in cancer patients: a randomized controlled trial. Support Care Cancer. 2012;20(6):1235-1242.
  21. Reid-Arndt SA, Matsuda S, Cox CR. Tai Chi effects on neuropsychological, emotional, and physical functioning following cancer treatment: a pilot study. Complement Ther Clin Pract. 2012;18(1):26-30.
  22. Ercoli LM, Petersen L, Hunter AM et al. Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial. Psychooncology 2015; 24(11): 1360–1367.
  23. Bray VJ, Dhillon HM, Bell ML et al. Evaluation of a web-based cognitive rehabilitation program in cancer survivors reporting cognitive symptoms after chemotherapy. J Clin Oncol 2017; 35(2): 217–225.
  24. Von AD, Carpenter JS, Saykin A et al. Advanced cognitive training for breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 2012; 135: 799–809.
  25. Kesler S, Hadi Hosseini SM, Heckler C et al. Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors. Clin Breast Cancer 2013; 13(4): 299–306.
  26. Carlson LE, Garland SN. Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients. Int J Behav Med. 2005;12(4):278-285.
  27. Carlson LE, Speca M, Faris P, Patel KD. One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients. Brain Behav Immun. 2007;21(8):1038-1049. 
  28. Kelly A. Biegler, M. Alejandro Chaoul & Lorenzo Cohen (2009) Cancer, cognitive impairment, and meditation, Acta Oncologica, 48:1, 18-26.
  29. Johns, S.A., Von Ah, D., Brown, L.F. et al. Randomized controlled pilot trial of mindfulness-based stress reduction for breast and colorectal cancer survivors: effects on cancer-related cognitive impairment. J Cancer Surviv 10, 437–448 (2016).
  30. Ashley M. Henneghan,Heather Becker,Michelle L. Harrison,Kelly Inselmann,Brandon Fico,Helen Schafer,Elizabeth King,Debra Patt,Shelli Kesler : A Randomized Control Trial of Meditation Compared to Music Listening to Improve Cognitive Function for Breast Cancer Survivors: Feasibility and Acceptability. Complementary Therapies in Clinical Practice, Volume 41, November 2020, 101228.
  31. Coro, D., Hutchinson, A., Dahlenburg, S. et al. The relationship between diet and cognitive function in adult cancer survivors: a systematic review. J Cancer Surviv 13, 773–791 (2019). 
  32. Zuniga, K.E.; Moran, N.E. Low Serum Carotenoids Are Associated with Self-Reported Cognitive Dysfunction and Inflammatory Markers in Breast Cancer Survivors. Nutrients 2018, 10, 1111.
  33. Orchard TS, Gaudier-Diaz MM, Weinhold KR, Courtney DeVries A. Clearing the fog: a review of the effects of dietary omega-3 fatty acids and added sugars on chemotherapy-induced cognitive deficits. Breast Cancer Res Treat. 2017;161(3):391-398.

Cet article est réservé aux abonnés

Déjà abonné ?

Retrouvez la suite de votre article en vous connectant à votre espace personnel.

Je m'identifie
Pas encore abonné ?

Accédez à des articles et conseils exclusifs en vous abonnant pour seulement 39 € / an.

Je m'abonne
Publicité

La sélection

Publicité

Les meilleurs livres et compléments alimentaires sélectionnés pour vous par NUTRISTORE, la boutique de la nutrition.

Découvrir la boutique logo Nutrivi
Cancer : un traitement simple et non toxique
Dr Laurent Schwartz
Cancer
Cancer
10,00 €
Voir le produit
Le régime cétogène contre le cancer
Christina Schlatterer-Gerd Knoll-Ulrike Kämmerer
Cancer
Régime cétogène
Cétogène
Cancer
19,89 €
Voir le produit
Combattre le cancer avec le régime cétogène
Magali Walkowicz
Cancer
Régime cétogène
Cancer
19,89 €
Voir le produit
Dépistage du cancer du sein, la grande illusion
Dr Bernard Duperray
Cancer
19,89 €
Voir le produit

A découvrir également