Tout savoir sur les liens entre déficit en vitamine D et autisme

Par Juliette Pouyat - Journaliste scientifique Publié le 13/12/2019 Mis à jour le 13/12/2019 Edition Abonné
Enquête

Si les causes exactes des troubles du spectre autistique (TSA) restent inconnues, ces derniers semblent notamment être liés à différents facteurs environnementaux. Et un déficit en vitamine D pourrait expliquer le rôle de ces facteurs dans l'autisme.

L’autisme fait partie des troubles du spectre autistique (TSA) qui comprennent également des pathologies comme le syndrome d’Asperger ou encore les troubles envahissants du développement. Les TSA apparaissent de manière précoce au cours de la petite enfance et persistent à l’âge adulte. L’autisme concernerait environ...

Références
  1. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med. 1995 Jan;25(1):63-77.
  2. Deng W, Zou X, Deng H, Li J, Tang C, Wang X, Guo X. The Relationship Among Genetic Heritability, Environmental Effects, and Autism Spectrum Disorders: 37 Pairs of Ascertained Twin Study. J Child Neurol. 2015 Nov;30(13):1794-9.
  3. Landrigan PJ. What causes autism? Exploring the environmental contribution. Curr Opin Pediatr. 2010 Apr;22(2):219-25. 
  4. Hamza M, Halayem S, Mrad R, Bourgou S, Charfi F, Belhadj A. Epigenetics' implication in autism spectrum disorders: A review. Encephale. 2017 Aug;43(4):374-381.
  5. Cannell JJ. Autism and vitamin D. Med Hypotheses. 2008;70(4):750-9. Epub 2007 Oct 24.
  6. Wang J, Udd KA, Vidisheva A, Swift RA, Spektor TM, Bravin E, Ibrahim E, Treisman J, Masri M, Berenson JR. Low serum vitamin D occurs commonly among multiple myeloma patients treated with bortezomib and/or thalidomide and is associated with severe neuropathy. Support Care Cancer. 2016 Jul;24(7):3105-10.
  7. Moore SJ, Turnpenny P, Quinn A, Glover S, Lloyd DJ, Montgomery T, Dean JC. A clinical study of 57 children with fetal anticonvulsant syndromes. J Med Genet. 2000 Jul;37(7):489-97. doi: 10.1136/jmg.37.7.489.
  8. Pitetzis DA, Spilioti MG, Yovos JG, Yavropoulou MP. The effect of VPA on bone: From clinical studies to cell cultures-The molecular mechanisms revisited. Seizure. 2017 May;48:36-43.
  9. Du L, Zhao G, Duan Z, Li F. Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation. Psychiatry Res. 2017 Jul;253:28-32.
  10. Muller CL, Anacker AMJ, Veenstra-VanderWeele J. The serotonin system in autism spectrum disorder: From biomarker to animal models. Neuroscience. 2016 May 3;321:24-41.
  11. Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014 Jun;28(6):2398-413.
  12. Husarova VM, Lakatosova S, Pivovarciova A, Babinska K, Bakos J, Durdiakova J, Kubranska A, Ondrejka I, Ostatnikova D. Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents. Psychiatry Investig. 2016 Mar;13(2):174-83.
  13. Brown AS, Sourander A, Hinkka-Yli-Salomäki S, McKeague IW, Sundvall J, Surcel HM. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol Psychiatry. 2014 Feb;19(2):259-64.
  14. Liu LC, Voors AA, van Veldhuisen DJ, van der Veer E, Belonje AM, Szymanski MK, Silljé HH, van Gilst WH, Jaarsma T, de Boer RA. Vitamin D status and outcomes in heart failure patients. Eur J Heart Fail. 2011 Jun;13(6):619-25.
  15. Sharifi A, Hosseinzadeh-Attar MJ, Vahedi H, Nedjat S. A randomized controlled trial on the effect of vitamin D3 on inflammation and cathelicidin gene expression in ulcerative colitis patients. Saudi J Gastroenterol. 2016 Jul-Aug;22(4):316-23.
  16. Bjorklund G, Saad K, Chirumbolo S, Kern JK, Geier DA, Geier MR, Urbina MA. Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiol Exp (Wars). 2016;76(4):257-268.
  17. Balato A, Schiattarella M, Lembo S, Mattii M, Prevete N, Balato N, Ayala F. Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid. Arch Dermatol Res. 2013 Apr;305(3):255-62.
  18. Dauletbaev N, Herscovitch K, Das M, Chen H, Bernier J, Matouk E, Bérubé J, Rousseau S, Lands LC. Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1. Br J Pharmacol. 2015 Oct;172(19):4757-71.
  19. Meguid NA, Dardir AA, Abdel-Raouf ER, Hashish A. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation. Biol Trace Elem Res. 2011 Oct;143(1):58-65. doi: 10.1007/s12011-010-8840-9.
  20. Yui K, Tanuma N, Yamada H, Kawasaki Y. Decreased total antioxidant capacity has a larger effect size than increased oxidant levels in urine in individuals with autism spectrum disorder. Environ Sci Pollut Res Int. 2017 Apr;24(10):9635-9644.
  21. Bhat M, Ismail A. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J Steroid Biochem Mol Biol. 2015 Aug;152:171-9.
  22. Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017 Mar 17;8:13. 
  23. Cannell, John & Holick, Michael & Vieth, Reinhold & Hollis, Bruce & Edu,. (2018). Autism and vitamin D the associations (submited).
  24. Mazumdar S, Liu KY, Susser E, Bearman P. The disappearing seasonality of autism conceptions in California. PLoS One. 2012;7(7):e41265.
  25. Baxter AJ, Brugha TS, Erskine HE, Scheurer RW, Vos T, Scott JG. The epidemiology and global burden of autism spectrum disorders. Psychol Med. 2015 Feb;45(3):601-13.
  26. Grant WB, Soles CM. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Dermatoendocrinol. 2009 Jul;1(4):223-8.
  27. Williams JG, Higgins JP, Brayne CE. Systematic review of prevalence studies of autism spectrum disorders. Arch Dis Child. 2006 Jan;91(1):8-15.
  28. Goswami R, Kochupillai N, Gupta N, Goswami D, Singh N, Dudha A. Presence of 25(OH) D deficiency in a rural North Indian village despite abundant sunshine. J Assoc Physicians India. 2008 Oct;56:755-7.
  29. Grant WB, Cannell JJ. Autism prevalence in the United States with respect to solar UV-B doses: An ecological study. Dermatoendocrinol. 2013 Jan 1;5(1):159-64.
  30. Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I.Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study. Environ Health Perspect. 2014 Jun 23.
  31. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol. 2013 Jul;136:54-8.
  32. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem. 2002 Jul 12;277(28):25125-32.
  33. Mazahery H, Camargo CA Jr, Conlon C, Beck KL, Kruger MC, von Hurst PR. Vitamin D and Autism Spectrum Disorder: A Literature Review. Nutrients. 2016 Apr 21;8(4):236.
  34. Magnusson C, Lundberg M, Lee BK, et al. Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study. BJPsych Open. 2016;2(2):170–172.

  35. Chen J, Xin K, Wei J, Zhang K, Xiao H. Lower maternal serum 25(OH) D in first trimester associated with higher autism risk in Chinese offspring. J Psychosom Res. 2016 Oct;89:98-101. 
  36. Vinkhuyzen AAE, Eyles DW, Burne THJ, Blanken LME, Kruithof CJ, Verhulst F, Jaddoe VW, Tiemeier H, McGrath JJ. Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Mol Psychiatry. 2018 Feb;23(2):240-246.

  37. Fernell E, Bejerot S, Westerlund J, Miniscalco C, Simila H, Eyles D, Gillberg C, Humble MB. Autism spectrum disorder and low vitamin D at birth: a sibling control study. Mol Autism. 2015 Jan 14;6:3.

  38. Wang T, Shan L, Du L, Feng J, Xu Z, Staal WG, Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry. 2016 Apr;25(4):341-50.
  39. García-Serna AM, Morales E. Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis. Mol Psychiatry. 2019 Jan 29.
  40. F. Fahmy, N. A. Sabri, M. H. El Hamamsy, M. El Sawi and O. K. Zaki. Vitamin D intake and sun exposure in autistic children. International Journal of  Pharmaceutical Sciences and research. 2016, December, ISSN (Online): 0975-8232.
  41. Hiraki LT, Major JM, Chen C, Cornelis MC, Hunter DJ, Rimm EB, Simon KC, Weinstein SJ, Purdue MP, Yu K, Albanes D, Kraft P. Exploring the genetic architecture of circulating 25-hydroxyvitamin D. Genet Epidemiol. 2013 Jan;37(1):92-8. 
  42. Coşkun S, Şimşek Ş, Camkurt MA, Çim A, Çelik SB. Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder. Gene. 2016 Aug 22;588(2):109-14.

  43. Li K, Shi Q, Yang L, Li X, Liu L, Wang L, Li Q, Wang G, Li CY, Gao TW. The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo. Br J Dermatol. 2012 Oct;167(4):815-21.
  44. Li J, Wang L, Yu P, Shi L, Zhang K, Sun ZS, Xia K. Vitamin D-related genes are subjected to significant de novo mutation burdens in autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet. 2017 Jul;174(5):568-577.
  45. Feng J, Shan L, Du L, Wang B, Li H, Wang W, Wang T, Dong H, Yue X, Xu Z, Staal WG, Jia F. Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder. Nutr Neurosci. 2017 Jun;20(5):284-290.

Cet article est réservé aux abonnés

Déjà abonné ?

Retrouvez la suite de votre article en vous connectant à votre espace personnel.

Je m'identifie
Pas encore abonné ?

Accédez à des articles et conseils exclusifs en vous abonnant pour seulement 39 € / an.

Je m'abonne
Publicité

La sélection

Publicité

Les meilleurs livres et compléments alimentaires sélectionnés pour vous par NUTRISTORE, la boutique de la nutrition.

Découvrir la boutique logo Nutrivi

A découvrir également

Back to top