Vous pensiez diriger votre vie grâce à votre volonté et vos aspirations personnelles ? Que nenni ! Les micro-organismes qui peuplent votre tube digestif vous influencent bien plus que vous ne le croyiez.
Intestin et microbiote
Comment expliquer que les bonnes bactéries de l'intestin permettent de mieux résister aux infections ? La recherche sur le microbiote intestinal apporte des explications sur les liens entre intestins et système immunitaire.
Depuis des années, des publicités pour produits lactés riches en « bifidobactéries » déguisent les ferments lactiques en véritables soldats du système immunitaire logés dans nos intestins. Sur quoi se basent ces allégations ? de plus en plus de recherches s'attellent à mieux comprendre les liens...
- Stinson, L. F., Payne, M. S., & Keelan, J. A. (2016). Planting the seed: Origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Critical Reviews in Microbiology, 43(3), 352–369.
- Shao, Y., Forster, S.C., Tsaliki, E. et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature 574, 117–121 (2019).
- Dominguez-Bello MG, De Jesus-Laboy KM, Shen N, et al. Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Nat Med. 2016;22(3):250-253.
- Huh SY, Rifas-Shiman SL, Zera CA, et al. Delivery by caesarean section and risk of obesity in preschool age children: a prospective cohort study. Archives of Disease in Childhood 2012;97:610-616.
- Zhou L, He G, Zhang J, Xie R, Walker M, Wen SW. Risk factors of obesity in preschool children in an urban area in China. Eur J Pediatr. 2011;170(11):1401-1406.
- Bager P, Wohlfahrt J, Westergaard T. Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin Exp Allergy. 2008;38(4):634-642.
- N.A. Mabbott, D.S. Donaldson, H. Ohno : Les fondamentaux de la pathologie digestive, © CDU-HGE/Editions Elesevier-Masson - Octobre 2014.
- I.R. Williams, A. Mahajan, Mucosal Immunol. 6 (2013) 666–677.
- E.A. Mayer, Nat. Rev. Neurosci. 12 (2011) 453–466.
- Peterson DA, McNulty NP, Guruge JL, Gordon JI. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe. 2007;2(5):328-339.
- Kawamoto S, Maruya M, Kato LM, et al. Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity. 2014;41(1):152-165.
- Ang et al. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells, Cell (2020).
- Göschl L, Scheinecker C, Bonelli M. Treg cells in autoimmunity: from identification to Treg-based therapies. Semin Immunopathol. 2019;41(3):301-314.
- Lee GR. The Balance of Th17 versus Treg Cells in Autoimmunity. Int J Mol Sci. 2018;19(3):730.
- Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology. 2012 May;142(5):1100-1101.e2.
- Joe Alcock, Carlo C. Maley, C. Athena Aktipis. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. BioEssays, 2014.
- Chen, L., et al. (2020) Modest Sodium Reduction Increases Circulating Short-Chain Fatty Acids in Untreated Hypertensives. Hypertension.
- Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015 Feb 9. pii: S1568-9972(15)00024-5.
- Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Diabetes. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. 2008 Jun;57(6):1470-81.
- Hollon J, Puppa EL, Greenwald B, Goldberg E, Guerrerio A, Fasano A. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients. 2015 Feb 27;7(3):1565-76.
- Vaarala O. et al. Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study. Arch Pediatr Adolesc Med. 2012 Mar 5.
- Kaliannan K, Wang B, Li XY, Kim KJ, Kang JX. A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia. Sci Rep. 2015;5:11276.
- Patel B, Schutte R, Sporns P, Doyle J, Jewel L, Fedorak RN. Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease. Inflamm Bowel Dis. 2002 Sep;8(5):340-6.
- Vojdani, A., Afar, D., & Vojdani, E. (2020). Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity. Journal of immunology research, 2020, 1438957.
- Bosman ES, Albert AY, Lui H, Dutz JP and Vallance BA (2019) Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome. Front. Microbiol. 10:2410.
- Li N, Neu J. Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells. J Nutr. 2009 Apr;139(4):710-4.
- Version actuelle le 01/07/2024
- le 17/11/2022
- le 14/11/2022
- le 02/11/2020
Cet article est réservé aux abonnés
Déjà abonné ?
Retrouvez la suite de votre article en vous connectant à votre espace personnel.
Je m'identifie
Pas encore abonné ?
Accédez à des articles et conseils exclusifs en vous abonnant pour seulement 39 € / an.
Je m'abonne Publicité
